Table 4.

Receiver operating characteristic curve analysis

Variable	AUC	Cut-off	P value	Sensitivity	Specificity
28-day mortality
Presepsin on Day 1 (pg/mL)	0.77	1373.00	0.004	0.82	0.77
Presepsin on Day 2 (pg/mL)	0.83	1581.00	0.000	0.86	0.68
Presepsin on Day 3 (pg/mL)	0.91	1819.00	0.000	1.00	0.82
Presepsin on Day 5 (pg/mL)	1.00	3014.00	0.000	1.00	1.00
ΔPresepsin Day 2 - Day 1 (pg/mL)	0.76	507.00	0.059	0.71	0.86
ΔPresepsin Day 3 - Day 1 (pg/mL)	0.91	−10.00	0.000	1.00	0.76
ΔPresepsin Day 5 - Day 1 (pg/mL)	0.79	2385.00	0.176	0.75	1.00
iPS-PLR	0.75	1.00	0.002	0.91	0.46
60-day mortality
Presepsin on Day 1 (pg/mL)	0.70	1373.00	0.063	0.75	0.76
Presepsin on Day 2 (pg/mL)	0.73	1581.00	0.052	0.75	0.67
Presepsin on Day 3 (pg/mL)	0.75	1819.00	0.134	0.80	0.81
Presepsin on Day 5 (pg/mL)	0.80	3014.00	0.134	0.80	1.00
ΔPresepsin Day 2 - Day 1 (pg/mL)	0.74	507.00	0.045	0.63	0.86
ΔPresepsin Day 3 - Day 1 (pg/mL)	0.85	−10.00	0.000	0.80	0.75
ΔPresepsin Day 5 - Day 1 (pg/mL)	0.72	2385.00	0.238	0.60	1.00
iPS-PLR	0.70	1.00	0.024	0.83	0.44
90-day mortality
Presepsin on Day 1 (pg/mL)	0.65	1373.00	0.142	0.64	0.74
Presepsin on Day 2 (pg/mL)	0.65	1581.00	0.190	0.60	0.63
Presepsin on Day 3 (pg/mL)	0.74	1545.00	0.085	0.83	0.73
Presepsin on Day 5 (pg/mL)	0.79	1399.00	0.082	0.83	0.73
ΔPresepsin Day 2 - Day 1 (pg/mL)	0.69	507.00	0.092	0.50	0.84
ΔPresepsin Day 3 - Day 1 (pg/mL)	0.87	−10.00	0.000	0.83	0.80
ΔPresepsin Day 5 - Day 1 (pg/mL)	0.74	244.00	0.108	0.67	0.82
180-day mortality
Presepsin on Day 1 (pg/mL)	0.65	1336.00	0.121	0.67	0.68
Presepsin on Day 2 (pg/mL)	0.68	1581.00	0.093	0.64	0.67
Presepsin on Day 3 (pg/mL)	0.80	1545.00	0.019	0.86	0.79
Presepsin on Day 5 (pg/mL)	0.77	1313.00	0.063	0.86	0.70
ΔPresepsin Day 2 - Day 1 (pg/mL)	0.73	507.00	0.022	0.55	0.89
ΔPresepsin Day 3 - Day 1 (pg/mL)	0.91	−10.00	0.000	0.86	0.86
ΔPresepsin Day 5 - Day 1 (pg/mL)	0.76	−23.00	0.051	0.71	0.80

AUC area under the curve, iPS inflammation-presepsin score, PLR platelet to lymphocyte ratio