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. 2021 Jun 3;13(11):2782. doi: 10.3390/cancers13112782

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Goodness of fit plots for the population quantitative systems pharmacology model using our clinical dataset of 19 patients. Legend: (a) Typical predictions (not considering interindividual variability) vs. measured concentrations/volumes for all species; (b) typical predictions (not considering interindividual variability) vs. measured concentrations/volumes, stratified for species; (c) individual predictions vs. measured concentrations for all species; (d) individual predictions vs. measured concentrations, stratified for species. Diagonal line: Line of identity. Tumor measurements marked as a complete response were set to a value of 0 mL and are not shown. Abbreviations—T_N: naïve T cells, T_CM: central memory T cells, T_EM: effector memory T cells, T_Eff: effector T cells, CD19⁺ tumor: CD19⁺ metabolic tumor volume.