Figure 3.

Measured T cell concentrations/metabolic tumor volumes (data points) and simulated typical (dashed lines) and individual (solid lines) model predictions for individual patients 1–16, and 18–19 in panels a–e and, as concentrations/volumes of all species were significantly higher, for patient 17 in separate panel (f). Legend: (a) Naïve CAR-T cells; (b) Central memory CAR-T cells; (c) Effector memory CAR-T cells; (d) Effector CAR-T cells; (e) CD19⁺ metabolic tumor volume; (f) Concentrations of naive, central memory, effector memory, and effector CAR-T cells as well as CD19⁺ metabolic tumor volume for patient 17. Abbreviations—T_N: naïve CAR-T cells, T_CM: central memory CAR-T cells, T_EM: effector memory CAR-T cells, T_Eff: effector CAR-T cells, CD19⁺ tumor: CD19⁺ metabolic tumor volume.