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. 2021 Jun 3;13(11):2782. doi: 10.3390/cancers13112782

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Determination of a clinical composite score (CCS) cut-off value for early response-prediction. (a) Correlation between model parameter V_max1 ((cells·µL⁻¹)·day⁻¹·mL⁻¹) and CCS Maximum naïve CAR-T cell concentration/Metabolic tumor volume at baseline ((cells·µL⁻¹) ·mL⁻¹). (b) Correlation plot as A but on a log-log scale and different labeling of the T cell expansion subpopulation. The dashed horizontal line marks the CCS cut-off value most predictive for allocation to the low expansion subpopulation, as determined using ROC analysis. (c) Kaplan–Meier probabilities for progression-free survival in patients below or exceeding the determined CCS_TN cut-off value. (d) Kaplan–Meier plots for overall survival in patients below or exceeding the determined CCS_TN cut-off value. Abbreviations—CCS_TN: clinical composite score for naïve CAR-T cells.

Determination of a clinical composite score (CCS) cut-off value for early response-prediction. (a) Correlation between model parameter V_max1 ((cells·µL⁻¹)·day⁻¹·mL⁻¹) and CCS Maximum naïve CAR-T cell concentration/Metabolic tumor volume at baseline ((cells·µL⁻¹) ·mL⁻¹). (b) Correlation plot as A but on a log-log scale and different labeling of the T cell expansion subpopulation. The dashed horizontal line marks the CCS cut-off value most predictive for allocation to the low expansion subpopulation, as determined using ROC analysis. (c) Kaplan–Meier probabilities for progression-free survival in patients below or exceeding the determined CCS_TN cut-off value. (d) Kaplan–Meier plots for overall survival in patients below or exceeding the determined CCS_TN cut-off value. Abbreviations—CCS_TN: clinical composite score for naïve CAR-T cells.