Landscape of genomic alterations identified by targeted deep sequencing in EUS-FNB specimens of patients with PDAC. (A) Co-mutation plot displaying integrated genomic data for 116 EUS-FNB specimens displayed as columns, including somatic mutations and somatic copy number variations for significantly mutated genes listed at the right (Top 10). The percentage of PDAC samples with an alteration of any type is noted at the left. Stage, age, sex, CA19-9 level, tumor mass size, and the number of any genetic alterations per each sample is presented on the top. Overall survival (OS) of each patient is shown on the bottom. (B) Variant allele frequency (VAF) distributions are analyzed, and median values are indicated by the central bar in the box and whiskers plots. PDAC, pancreatic ductal adenocarcinoma; EUS-FNB, endoscopic ultrasound-guided fine-needle biopsy; AMP, copy number amplification; DEL, copy number deletion; FUSION, structure variation; TRUNC, truncating mutation; NONTRUNC, non-truncating mutation.