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. 2021 Jun 3;13(11):2791. doi: 10.3390/cancers13112791

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kaplan–-Meier plots for genetic alterations significantly associated with survival. The Kaplan–Meier plots indicate genes significantly (p < 0.05) associated with the survival of patients with pancreatic ductal adenocarcinoma (PDAC). (A) Single nucleotide variant (SNV) of NF1 (p = 0.0061), (B) copy number variation (CNV) of SMAD4 (p = 0.0367), and (C) loss-of-function (LOF) mutation of CDKN2A (p = 0.0025) were related to survival in PDAC. (D) LOF mutation of CDKN2A and worse prognosis was verified by TCGA data.