Figure 2.

BET protein mediated transcription elongation. (A) The BET family of proteins contain two bromodomains (BD1, BD2). BRD4 is expressed as both a long and short isoform. BRD4 long contains a unique c-terminal domain (CTD) that interacts with P-TEFb, whereas BRD4 short lacks the CTD. (B) Schematic representation of the role of BRD4 in assembly of the transcriptional machinery involved in stress-induced transcription elongation of target genes in the heart. TF, transcription factor; P-TEFb, positive transcription elongation factor b; SE, superenhancer; TSS, transcription start site; red-line, H3K27Ac marks on the SE.