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(A) Schematic representation of mitochondria-targeted nanoformulations loaded with hydrophilic and hydrophobic drugs. These NPs can also be loaded with Mitochondria-targeted genes. (B) Approaches for drug-loaded NP entry within a target cell. (C) of Mito-Porter approach for targeting of cancer-cell mitochondria. (D) Membrane fusion of Mito-Porter with OMM and IMM and the delivery of mitochondria-specific drugs and genes.
