Table 2.
BRCA1/2 Pathogenic Mutation Rates by Subgroups
| Characteristics | Number of Patients | BRCA1/BRCA2 n (%) | P-value | |
|---|---|---|---|---|
| Age at diagnosis (years) | <40 | 85 | 28 (32.9%) | 0.034 |
| ≥40 | 112 | 22 (19.6%) | ||
| Diagnosed at any age with two or more diagnoses of breast cancer at any age (synchronously or asynchronously) | Yes | 29 | 12 (41.4) | 0.032 |
| No | 168 | 38 (22.6) | ||
| Diagnosed at age 50 years or younger with: 1 or more close relatives with breast cancer at any age, 1 or more close relatives with pancreatic cancer, or 1 or more close relatives with prostate cancer (Gleason score ≥7) | Yes | 74 | 28 (37.8) | 0.002 |
| No | 123 | 22 (17.9) | ||
| Diagnosed at any age with 1 or more close relatives with breast cancer diagnosed at age 50 years or younger | Yes | 47 | 19 (40.4) | 0.007 |
| No | 150 | 31 (20.7) | ||
| Nationality | Jordanian | 170 | 41 (24.1) | 0.307 |
| Others | 27 | 9 (33.3) | ||