Table 4.

Histological Features of Wound Healing in Animals Treated Topically with OFI-SNEDDS on Day 7

	RE	GT	CD	IC	Inflammation Phase	Proliferation Phase	Remodeling Phase
Untreated Control	–	+	+	++	++	++	–
Vehicle-treated	–	++	+	++	++	++	–
OFI	+	+++	+	±	+	+++	++
OFI-SNEDDS	+	+	++	–	+	++	+++
Positive Control	+	++	++	±	++	+++	++

Notes: (–) Absence of the histological feature, (+) Low-degree, (++) Intermediate-degree, (+++) High-degree, (±) Absence or Low-degree feature.

Abbreviations: RE, Re-epithelization; GT, Granulation tissue; CD, Collagen deposition; IC, Inflammatory cell infiltration.