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. 2021 Jun 8;4(7):e202000874. doi: 10.26508/lsa.202000874

Figure S2. PGRN deficiency does not cause obvious behavioral changes in the open-field and Y-maze tests.

Figure S2.

(A) 4.5-mo-old WT, Grn−/−, 5XFAD and 5XFAD Grn−/− mice were subject to open-field test. Total distance traveled for 5 min were plotted. Data represented are mean ± SEM, WT (male), n = 10; Grn−/− (male), n = 7; 5XFAD (male), n = 5; 5XFAD Grn−/− (male), n = 8; WT (female), n = 12; Grn−/− (female), n = 10; 5XFAD (female), n = 10; 5XFAD Grn−/− (female), n = 5, one-way ANOVA. (B) 4.5-mo-old WT, Grn−/−, 5XFAD and 5XFAD Grn−/− mice were subject to Y-maze test. Percentage of spontaneous alternation behavior in the Y-maze was plotted. Data represented are mean ± SEM, WT (male), n = 12; Grn−/− (male), n = 7; 5XFAD (male), n = 5; 5XFAD Grn−/− (male), n = 8; WT (female), n = 9; Grn−/− (female), n = 10; 5XFAD (female), n = 10; 5XFAD Grn−/− (female), n = 5, one-way ANOVA, *P < 0.05, **P < 0.01.