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. 2021 Jun 11;4(7):e202101038. doi: 10.26508/lsa.202101038

Figure 5. WBP2 negatively regulates the assembly of the microprocessor complex.

Figure 5.

(A-i) QC for the overexpression of WBP2 in different subcellular fractions and the lack of effect on the expression level of the microprocessor complex components in T47D cells. (A-ii) Analysis of the microprocessor complex assembly upon WBP2 overexpression upon DGCR8 pull-down in T47D cells. (A-iii) Analysis of the microprocessor complex assembly upon WBP2 overexpression upon Drosha pull-down in T47D cells. (B-i) QC for the depletion of WBP2 in different subcellular fractions and the lack of effect on the expression level of the microprocessor complex components in T47D cells. (B-ii) Analysis of the microprocessor complex assembly upon WBP2 knockdown upon DGCR8 pull-down in T47D cells. (C-i) QC for the overexpression of WBP2 in different subcellular fractions and the lack of effect on the expression level of the microprocessor complex components in MCF-7 cells. (C-ii) Analysis of the microprocessor complex assembly upon WBP2 overexpression upon DGCR8 pull-down in MCF-7 cells. (C-iii) Analysis of the microprocessor complex assembly upon WBP2 overexpression upon Drosha pull-down in MCF-7 cells. (D-i) QC for the depletion of WBP2 in different subcellular fractions and the lack of effect on the expression level of the microprocessor complex components in MCF-7 cells. (D-ii) Analysis of the microprocessor complex assembly upon WBP2 knockdown upon DGCR8 pull-down in MCF-7 cells.