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. 2021 Jun 11;4(7):e202101038. doi: 10.26508/lsa.202101038

Figure 6. The tumor-suppressive role of the microprocessor complex is inversely affected by WBP2.

Figure 6.

(A, B, C) Down-regulation of (A) DGCR8, (B) DDX5, and (C) DDX17 transcript levels in 1,085 breast tumors as compared with 291 controls (P-values < 0.01). (D, E, F, G) Analysis of the correlation of (D) DGCR8, (E) DDX5, (F) DDX17 and (G) DGCR8/DDX5/DDX17 gene expression signature with the relapse-free survival of breast cancer samples. (H) Analysis of the 3D proliferation rate of MCF-7 cells upon DGCR8 knockdown or DGCR8/WBP2 double knockdown (i), or DGCR8 overexpression or DGCR8/WBP2 co-overexpression. (I) Analysis of the 3D proliferation rate of T47D cells upon DGCR8 knockdown or DGCR8/WBP2 double knockdown (i), or DGCR8 overexpression or DGCR8/WBP2 co-overexpression.