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. 2021 Jun 14;6(3):135–143. doi: 10.1016/j.synbio.2021.06.002

Fig. 5.

Fig. 5

The association of the serum metabolome and clinical phenotypes. (a) Boxplot of serum WBC between COVID-19 (Case) and non-COVID-19 (Control) patients. (b) The level of serum metabolite neg-289 in COVID-19 (Case) and non-COVID-19 (Control) patients. The metabolite's name of neg-289 is chlorogenic acid methyl ester (CME). P values were labelled above the boxplots (a, b). (c) Heat map showed the association of serum metabolome and clinical phenotypes in 15 patients. RBC, red blood cell; WBC, white blood cell; LYM, lymphocyte; HGB, haemoglobin; PLT, platelet count; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, albumin; TBIL, total bilirubin; BUN, blood urea nitrogen; CREAT, creatinine; CK, creatine kinase; LDH, Lactate dehydrogenase; MGB, myoglobin; Pro-BNP, pro B type natriuretic peptide; CTnI, cardiac troponin I; PT, prothrombin time; INR, international normalized ratio; PCT, procalcitonin level; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate. (d) The significant association of several specific nasopharyngeal bacteria and serum metabolome. Red indicates the positive correlation and blue indicates the negative correlation (c–d). *, P < 0.05; **, P < 0.01.