Table 2.
Detailed mapping results for the fragment-bound protein with UniProt ID P00918 bound by fragment 1SA (PDB ID 2HNC)
| Hot Spotsc |
||||||||
|---|---|---|---|---|---|---|---|---|
| PDB IDa | Overlapb | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
| 2HNC_A | map | 00(25) | 01(16) | 02(12) | 03(12) | 04(09) | 05(08) | 06(04) |
| 2HNC_A | frag_hs | 100% | - | 10% | 70% | 30% | - | - |
| 2HNC_A | hs_frag | 60% | - | 1% | 97% | 10% | - | - |
| 2HNC_A | max_hs | 68% | - | 5% | 32% | 68% | - | 14% |
| 2HNC_A | max_lig | 68% | - | 1% | 97% | 88% | - | 26% |
a
PDB ID and chain ID of the fragment-bound protein that was mapped by FTMap.
b
Mapping results: map – hot spots ranking, with the number of probe clusters in parenthesis; frag-hs - percentage of the fragment covered by the hot spot; frag – percentage of hot spot covered by the fragment; max_hs - percent coverage of the largest ligand by the hot spot; max_lig - percent coverage of the hot spot by the largest ligand.
c
The 7 hot spots with the highest number of probe clusters.