Fig. 2.

Annual cost per patient by Expanded Disability Status Scale (EDSS) classification group adjusted to $US, year 2019 values, and cost ratios for bottom-up studies. Note that Chanatittarat et al. [54] did not report any cost by EDSS classification. °Data courtesy of Prof. Gisela Kobelt [44] via personal communication. ¹Information about EDSS level was unavailable for two patients in da Silva et al. [48]. ²EDSS information was missing for 20 patients in Boyko et al. [47]. ³To obtain the cost per patient per year for the study by Torabipour et al. [46] from Iran, we annualized resources used by assuming that collected data on resources were representative of patient use over the whole year