Table 5:
Comparison of dihydroceramide concentrations
| Metabolite | HC Mean (SD), ng/ml | RRMS Mean (SD), ng/ml | PMS Mean (SD), ng/ml | HC v RRMS | HC v PMS | RRMS v PMS | |||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Beta±SEa | p-valuea | Beta±SEa | p-valuea | Beta±SEa | p-valuea | ||||
|
| |||||||||
| DH-Cer18:0 | 2.01 (3.52) |
2.07 (3.15) |
2.2 (3.95) |
0.14±0.15 | 3.31E-01 | 0.13±0.17 | 4.29E-01 | −0.01±0.14 | 9.40E-01 |
|
| |||||||||
| DH-Cer20:0 | 8.58 (5.76) |
12.29 (6.43) |
16.93 (6.99) |
0.4±0.08 | 2.71E-06 | 0.76±0.1 | 3.38E-14 | 0.36±0.08 | 1.24E-05 |
|
| |||||||||
| DH-Cer22:0 | 21.99 (8.5) |
24.12 (10.21) |
28.31 (10.48) |
0.06±0.06 | 3.84E-01 | 0.2±0.07 | 6.95E-03 | 0.14±0.06 | 2.15E-02 |
|
| |||||||||
| DH-Cer24:0 | 174.77 (72.93) |
216.09 (81.15) |
236.39 (90.48) |
0.24±0.06 | 1.29E-04 | 0.29±0.07 | 7.20E-05 | 0.04±0.06 | 4.66E-01 |
|
| |||||||||
| DH-Cer26:0 | 1.93 (1.35) |
2.42 (1.57) |
3.03 (2.16) |
0.21±0.09 | 1.56E-02 | 0.25±0.1 | 1.25E-02 | 0.04±0.08 | 6.58E-01 |
|
| |||||||||
| DH-HexCer16:0 | 8.67 (4) |
9.11 (4.5) |
10.51 (4.62) |
0.001±0.07 | 9.95E-01 | 0.15±0.08 | 7.75E-02 | 0.15±0.07 | 3.73E-02 |
|
| |||||||||
| DH-HexCer18:0 | 0.83 (0.33) |
0.88 (0.28) |
0.89 (0.34) |
0.06±0.05 | 2.14E-01 | 0.08±0.06 | 1.90E-01 | 0.01±0.05 | 7.95E-01 |
|
| |||||||||
| DH-HexCer20:0 | 4.59 (3.37) |
4.36 (3.45) |
5.44 (3.35) |
−0.05±0.09 | 5.40E-01 | 0.2±0.1 | 4.67E-02 | 0.25±0.08 | 2.89E-03 |
|
| |||||||||
| DH-HexCer22:0 | 15.5 (5.77) |
18.45 (6.52) |
21.29 (8.1) |
0.19±0.05 | 5.31E-04 | 0.33±0.06 | 1.25E-07 | 0.14±0.05 | 6.06E-03 |
|
| |||||||||
| DH-HexCer24:0 | 43.48 (16.6) |
46.24 (16.76) |
52.85 (17.81) |
0.04±0.06 | 4.66E-01 | 0.16±0.07 | 1.94E-02 | 0.12±0.06 | 4.38E-02 |
|
| |||||||||
| DH-HexCer26:0 | 12.51 (12.16) |
6.54 (6.02) |
5.26 (4.92) |
−0.61±0.12 | 3.00E-07 | −0.82±0.13 | 2.49E-09 | −0.2±0.11 | 6.96E-02 |
|
| |||||||||
| DH-LacCer16:0 | 8.35 (3.02) |
8.17 (2.68) |
9.07 (2.52) |
−0.01±0.05 | 7.72E-01 | 0.15±0.05 | 3.37E-03 | 0.17±0.04 | 1.73E-04 |
a
Multivariable linear regression models including age, sex, race as covariates. Bolded p-values correspond to those that met the threshold of significance based on the Bonferroni correction.
HC: Healthy Controls; MS: Multiple Sclerosis; RRMS: Relapsing-Remitting MS; PMS: Progressive MS; SD: Standard Deviation; SE: Standard Error