. Author manuscript; available in PMC: 2021 Sep 4.

Published in final edited form as: Mult Scler. 2020 Dec 14;27(10):1506–1519. doi: 10.1177/1352458520971816

Table 8.

Association of baseline lipid concentration with longitudinal rates of retinal atrophy

Lipid	GCIPL			pRNFL
	Beta ± SE (unadjusted)^a	P-value (unadjusted)^a	P-value (adjusted)^b	Beta ± SE (unadjusted)^a	P-value (unadjusted)^a	P-value (adjusted)^b
Hex-Cer24:1	−0.116 ± 0.046	0.012	0.010	−0.14 ± 0.095	0.14	0.08
Hex-Cer22:0	−0.138 ± 0.053	0.01	0.009	−0.305 ± 0.107	0.004	0.001
DH-HexCer22:0	−0.158 ± 0.053	0.003	0.002	−0.358 ± 0.106	0.001	<0.001

Univariable mixed-effects linear regression with subject-specific and eye-specific random intercepts and random slopes in time

Multivariable mixed effects linear regression including age, sex, race, MS subtype, ON history and their respective interactions with follow-up time

GCIPL: Ganglion Cell + Inner Plexiform Layer; pRNFL: Peripapillary Retinal Nerve Fiber Layer; SE: Standard Error; MS: Multiple Sclerosis; ON: optic neuritis