Table 2.
Association of clinical variables with eGFR variability
| Variables | Multivariate | |
|---|---|---|
| β (95% CI) | p-value | |
| Age (per SD =9) | −0.023 (−0.054, 0.009) | 0.16 |
| Female | 0.051 (−0.002, 0.104) | 0.06 |
| Race | ||
| white | 0 (ref) | |
| black | 0.068 (0.012, 0.124) | 0.02 |
| hispanic | −0.054 (−0.134, 0.025) | 0.18 |
| other | −0.089 (−0.268, 0.091) | 0.33 |
| BMI (per SD=5.7) | 0.007 (−0.017, 0.032) | 0.56 |
| Smoking | ||
| never | 0 (ref) | |
| former | −0.005 (−0.055, 0.046) | 0.86 |
| current | 0.220 (0.142, 0.298) | <0.001 |
| Prevalent CVD | 0.045 (−0.015, 0.105) | 0.14 |
| Prevalent HF | 0.226 (0.096, 0.356) | 0.001 |
| Anti-HTN medications | ||
| Diuretics | 0.052 (0.004, 0.10) | 0.04 |
| ACEI/ARB | 0.093 (0.042, 0.143) | <0.001 |
| SBP (per SD=15) | 0.043 (0.013, 0.072) | 0.005 |
| DBP (per SD=12) | −0.040 (−0.072, −0.007) | 0.02 |
| eGFR (at 6m; per SD= 21 decrease) | 0.098 (0.072, 0.123) | <0.001 |
| ACR (at baseline; per doubling) | 0.048 (0.033, 0.063) | <0.001 |
| Total cholesterol (per SD=41) | 0.024 (−0.001, 0.050) | 0.06 |
Abbreviations: SD, standard deviation; CVD, cardiovascular disease; HF, heart failure; HTN, hypertension; ACEI, angiotensin-converting-enzyme inhibitor; ARB, angiotensin II receptor blocker; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; ACR, albumin-to-creatinine ratio.