Table 3.

Association of eGFR variability with CVD events and all-cause mortality

Cardiovascular Events
	CONTINUOUS	DISTRIBUTION OF EGFR VARIABILITY
	per SD greater =0.06	< 0.05	0.05 – 0.07	> 0.07 – 0.11	> 0.11
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
N	7520	1771	1965	1933	1851
CVD EVENTS	370	71	88	100	111
RATE (%/YR)	2.06	1.69	1.88	2.15	2.52
UNADJUSTED	1.12 (1.03, 1.23)	1.00 (ref)	1.15 (0.84, 1.58)	1.29 (0.95, 1.76)	1.53 (1.13, 2.07)
MODEL 1	1.15 (1.05, 1.26)	1.00 (ref)	1.18 (0.85, 1.62)	1.33 (0.97, 1.81)	1.62 (1.20, 2.21)
MODEL 2	1.05 (0.95, 1.16)	1.00 (ref)	1.17 (0.85, 1.62)	1.19 (0.87, 1.63)	1.34 (0.98, 1.84)
All-Cause Mortality
	CONTINUOUS	DISTRIBUTION OF EGFR VARIABILITY
	per SD greater =0.06	< 0.05	0.05 – 0.07	> 0.07 – 0.11	> 0.11
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
N	7520	1771	1965	1933	1851
MORTALITY	154	30	32	34	58
RATE (%/YR)	1.09	0.92	0.88	0.93	1.66
UNADJUSTED	1.30 (1.18, 1.44)	1.00 (ref)	0.89 (0.53, 1.49)	0.91 (0.55, 1.52)	1.77 (1.13, 2.77)
MODEL 1	1.35 (1.21, 1.50)	1.00 (ref)	0.92 (0.55, 1.54)	0.95 (0.57, 1.58	1.90 (1.21, 2.99)
MODEL 2	1.29 (1.14, 1.45)	1.00 (ref)	0.89 (0.53, 1.49)	0.87 (0.52, 1.45)	1.57 (0.99, 2.49)

Model 1: adjusted for age, sex, race, randomized arm.

Model 2: Model 1 + baseline history of CVD, history of heart failure, current smoking status, BMI, LDL, total cholesterol, ACR (baseline), eGFR (18m), systolic blood pressure (18m), diastolic blood pressure (18m), ACE/ARB (18m), diuretics (18m), calcium channel blocker (18m) and fasting status.

Abbreviations: SD, standard deviation; CVD, cardiovascular disease; CI, confidence interval; BMI, body mass index; LDL, low-density lipoprotein; ACEI, angiotensin-converting-enzyme inhibitor; ARB, angiotensin II receptor blocker; eGFR, estimated glomerular filtration rate; ACR, albumin-to-creatinine ratio.