Table 3.
Foveal retinal layer thicknesses and comparisons between AQP4 non-ON and HC eyes
| Layer | HC mean (SD), μm (n=148 eyes) | AQP4 non-ON mean (SD), μm (n=78 eyes) | AQP4 non-ON vs HC | |
|---|---|---|---|---|
| Beta (95% CI)a | P-valuea | |||
| RNFL | 7.8 (1.1) | 7.7 (0.9) | 0.01 (−0.29 to 0.31) | 0.95 |
| GCIPL | 34.0 (11.5) | 32.0 (9.6) | −0.69 (−4.16 to 2.77) | 0.70 |
| INL | 25.8 (6.9) | 26.3 (6.9) | 1.50 (−0.72 to 3.72) | 0.18 |
| OPL | 15.9 (3.8) | 16.3 (3.8) | 0.59 (−0.65 to 1.82) | 0.35 |
| ONL | 93.0 (11.3) | 88.6 (13.6) | −4.01 (−8.00 to −0.02) | 0.049 |
| IS | 22.9 (0.7) | 22.7 (1.0) | −0.32 (−0.60 to −0.03) | 0.029 |
| OS | 32.2 (1.7) | 32.0 (2.2) | −0.23 (−0.91 to 0.44) | 0.50 |
| ONLPS | 148.1 (11.6) | 143.3 (14.0) | −4.57 (−8.65 to −0.49) | 0.028 |
| FT | 263.7 (22.7) | 257.6 (23.7) | −3.55 (−10.97 to 3.87) | 0.35 |
a
Derived from generalized estimating equation models, adjusted for age, sex and race.
HC: healthy controls; AQP4: aquaporin-4; ON: optic neuritis; SD: standard deviation; CI: confidence interval; RNFL: retinal nerve fiber layer; GCIPL: ganglion cell+inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; IS: inner photoreceptor segment; OS: outer photoreceptor segment; ONLPS: outer nuclear layer & photoreceptor segments (ONL + IS + OS); FT: retinal thickness at the fovea (within a circle of a 1 mm diameter centered at the fovea)