. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Mult Scler. 2020 Dec 14;27(11):1738–1748. doi: 10.1177/1352458520977771

Table 4.

Letter acuity scores and comparisons between AQP4 non-ON and HC eyes

Letter acuity score	HC median (IQR) (n=116 eyes)	AQP4 non-ON median (IQR) (n=70 eyes)	AQP4 non-ON vs HC
Letter acuity score	HC median (IQR) (n=116 eyes)	AQP4 non-ON median (IQR) (n=70 eyes)	Beta (95% CI)^a	P-value^a
100% contrast (HCLA)	59 (55–64)	55 (49–62)	−3.63 (−6.13 to −1.13)	0.004
2.5% contrast (LCLA)	33 (25–37)	24.5 (14–32)	−6.80 (−9.92 to −3.67)	<0.001
1.25% contrast (LCLA)	20 (13.5–27.5)	9 (3–20)	−5.32 (−10.75 to 0.11)	0.055

Derived from generalized estimating equation models, adjusted for age, sex and race

HC: healthy controls; AQP4: aquaporin-4; ON: optic neuritis; IQR: interquartile range; CI: confidence interval; HCLA: high-contrast letter acuity; LCLA: low-contrast letter acuity