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. 2021 May 31;8:683357. doi: 10.3389/fmed.2021.683357

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Copyright © 2021 Farkh, Ellouze, Gounelle, Sad Houari, Duchemin, Proulle, Fontenay, Delavenne and Jourdi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of FXa inhibitors on dRVVT and SCT assays. Samples from patients receiving direct oral FXa inhibitors were tested using dRVVT (n = 38 in A and n = 39 in C) and SCT (n = 36 in B and n = 39 in D) screen assays. Only samples having elevated screen ratio (i.e., ≥ 1.20) were subsequently analyzed using confirm assays. Screen and confirm ratios are plotted as a function of rivaroxaban (A,B) or apixaban (C,D) plasma concentrations measured using specific anti-Xa assays. Dashed line corresponds to the cutoff value of 1.20.