Table 1.

FXa inhibitors concentrations in pre- and post-filtration samples.

	Rivaroxaban samples			Apixaban samples
	Pre-filtration	Post-filtration	% of neutralization	Pre-filtration	Post-filtration	% of neutralization
Anti-Xa assay (ng/mL)	63 [26; 363]	<18 [<18; 22]		126 [33; 370]	<18
HPLC-MS/MS (ng/mL)	64.8 [17.6; 311.4]	<2 [<2; 2.4]	100 [99.7; 100]	92.1 [37.1; 390.7]	<2 [<2; 9.6]	100 [97.4; 100]

Median [min; max] values are reported. Rivaroxaban concentration was measured using specific anti-Xa assay or HPLC-MS/MS in 30 and 37 samples, respectively. Apixaban concentration was measured in 38 and 41 samples, respectively. Total neutralization (100%) corresponds to xaban concentration below the lower limit of quantification of HPLC-MS/MS (i.e., 2 ng/mL).