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. 2021 May 31;8:675935. doi: 10.3389/fnut.2021.675935

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Copyright © 2021 Kalafati, Lenz, Ertaylan, Arts, Evelo, van Greevenbroek, Blaak, Adriaens and Kutmon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysfunctional lipid and glucose metabolism, mitochondrial respiration, and BCAA catabolism associated with high macrophage frequencies in SAT. The gene-process network illustrates the top 10 GO biological processes enriched for downregulated genes for the M3 vs. M0 group comparison. Downregulated gene nodes are visualized as hexagons and process nodes as circles. The edges in the network show the involvement of genes in biological processes to which they are connected to. The differential gene expression is visualized on the gene nodes using a color gradient from blue (downregulated) over white (not changed) to red (upregulated). The overall distribution of gene expression changes for genes associated with a biological process is visualized using a pie chart divided into upregulated, downregulated, and not significantly changed genes.