Table 2.

Cox regression analysis for overall survival in the study cohort (N = 106)

Variables	Univariate			Multivariate
	HR	95% CI	P‐value	HR	95% CI	P‐value
Patient population, N = 106
Sex (male vs. female)	0.76	0.48 – 1.21	0.25
Sex (female vs. male)	1.31	0.83 – 2.08	0.25
Age	0.99	0.96 – 1.01	0.37
Charlson comorbidity index	0.95	0.82 – 1.10	0.47
Squamous cell carcinoma	1.09	0.67 – 1.77	0.74
Pre‐existent weight loss >2% a	1.30	0.77 – 2.21	0.33
Hypoalbuminaemia b	1.49	0.87 – 2.53	0.14
Elevated C‐reactive protein (continues variable) c	1.00	0.99 – 1.01	0.23
Anaemia d	1.30	0.79 – 2.15	0.31
Elevated LDH e	1.12	0.69 – 1.81	0.65
Weight loss >2% at Week 6	2.39	1.51 – 3.79	<0.001	2.00	1.12–3.40	0.019
Baseline body mass index	0.98	0.93 – 1.03	0.46
>1 metastasis location	1.46	0.90 – 2.38	0.26

CI, confidence interval; HR, hazard ratio; LDH, lactate dehydrogenase. Bold values denote statistical significance at the p<0.05 level. Underlined values were considered potential prognostic factors and were included in multivariate analysis.

^aPre‐existent weight loss: >2% weight loss in 6 months prior to baseline.

^bHypoalbuminaemia: albumin level <32 g/L.

^cC‐reactive protein, continuous variable.

^dAnaemia: haemoglobin content <8.2 mmol/L.

^eLDH > 248 U/L.