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. 2021 Mar 24;12(3):704–716. doi: 10.1002/jcsm.12692

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© 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Serum insulin‐like growth factor binding protein 2 (IGFBP2) level is increased in pancreatic ductal adenocarcinoma (PDAC) patients with severe malnutrition and correlates with shorter survival. Serum level of IGFBP2 was measured by enzyme‐linked immunosorbent assay. (A) Serum IGFBP2 levels in healthy control and in patients with PDAC. (B) Higher serum IGFBP2 level concentrations in PDAC patients with Patient‐Generated Subjective Global Assessment (PG‐SGA) ≥9 compared with patients with PG‐SGA < 9. ***P < 0.001. (C) Receiver operating characteristic curve of serum IGFBP2 level for PG‐SGA. (D) Association between serum IGFBP2 levels and overall survival. Significance (P = 0.003) was analysed with the Kaplan–Meier survival curves.