Figure 2.

Consensus network analysis of RET vs. disuse responses in young muscle. Panel (A): Consensus modules shown are those differentially regulated by RET and/or disuse in young muscle. Red and blue shading denote significant up‐regulation and down‐regulation following each condition (vs. baseline), respectively. In all cases, functional summaries are representative of enriched Gene Ontology/Reactome Pathway terms for each given module. Also provided is the top ranked hub gene for each module per consensus network. Panels (B)–(D): Hub gene network visualizations for consensus modules concordantly or inversely regulated by RET and disuse in young muscle. Each visualization illustrates all corresponding hub genes of the given consensus module on a per condition basis, with dual‐coloured nodes thus representing genes that are overlapping consensus module hubs for both given conditions. Red borders (if any) illustrate the overlapping hub genes in each case that also appear among the corresponding list of RRHO genes for that particular scenario (e.g. up‐regulated by RET but down‐regulated by disuse). RET, resistance exercise training; RRHO, rank–rank hypergeometric overlap.