Figure 2.

Diversity of the population of C. acnes. A population tree is shown based on a phylogenomic comparison relying on core genome-located nucleotide polymorphisms. Distinct phylotypes of C. acnes are highlighted as six main phylotypes IA₁, IA₂, IB, IC, II, III, and 10 SLST types A-L. SLST types F, G, H, K, L correspond to phylotypes IA₂, IC, IB, II, and III, respectively. Please note that SLST types A–E are distinct clades of phylotype IA₁. In particular, SLST types D and E are distinct from acne-associated SLST types A–C. In total, 286 publicly available C. acnes genomes were analyzed and the closed genome of strain KPA171202 (phylotype IB, SLST type H) was taken as reference [modified from Brüggemann (2019)].