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. 2021 May 31;15:644047. doi: 10.3389/fncel.2021.644047

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Copyright © 2021 Suleimanova, Talanov, van den Maagdenberg and Giniatullin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of Aδ-fiber. (A) Schematic presentation of the Aδ-fiber with the diameter 5 μm and node of Ranvier 2 × 2 μm. (B) The membrane Na_V, K_V, and K_Ca currents relevant to the model of Aδ-fiber. (C) Comparison of Na_V1.1 currents, that evoked by a voltage step to -10 mV of WT with the L263V (Ca), L1670W (Cb), and M145T (Cc) mutations.