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. 2021 May 31;15:644047. doi: 10.3389/fncel.2021.644047

FIGURE 2.

FIGURE 2

The activation and inactivation properties of WT and NaV1.1 mutants. The comparison of voltage dependence of activation and fast inactivation of NaV1.1 WT and mutants L263V (Aa), L1670W (Ba), L1649Q (Ca), Q1478K (Da), R1648H (Ea), and M145T (Fa). The comparison of voltage dependence of slow inactivation development of NaV1.1 WT and gain-of-function mutants L263V (Ab), L1670W (Bb), L1649Q (Cb), Q1478K (Db), and R1648H (Eb). The dotted line shows experimental results from Kahlig et al. (2008) for the L263V mutation, Dhifallah et al. (2018) for the L1670W mutation, Cestele et al. (2008) for the L1649Q mutation, Cestele et al. (2013) for the Q1478K mutation, and Mantegazza et al. (2005) for the M145T mutation. Mutations were compared with the respective WT data from the publication that presented experimental data for the mutations.