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. 2021 May 31;15:644047. doi: 10.3389/fncel.2021.644047

FIGURE 4.

FIGURE 4

Testing the role of branching and multiple ATP release events in firing of the WT and mutant Aδ-fibers. (A) Schematic presentation of a dendritic tree with two branches and two ATP release events. (B) Firing activity of the L263V NaV1.1 mutant (red line) and WT (Kahlig et al., 2008) fiber (black line) with simultaneous ATP release events. (C) The L263V mutant (red line) and WT (Kahlig et al., 2008) fiber (black line) with ATP release with an interval of 5 ms. (D) The L263V mutant (red line) and WT (Kahlig et al., 2008) fiber (black line) with an 10-ms interval. (E) The L263V mutant (red line) and WT (Kahlig et al., 2008) fiber (black line) with an 15-ms interval. (F) The L1670W (red line) and WT (Dhifallah et al., 2018) fiber (black line) with an interval of 15 ms. (G) Firing in the loss-of-function mutant M145T (red line) and WT (Mantegazza et al., 2005) fiber (black line) with an ATP release interval of 15 ms. Note that branching and multiple ATP release increased the firing in the case of a gain-of function but reduced in the case of a loss-of-function. ATP signaling is limited by partial hydrolysis.