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. 2021 May 31;15:644047. doi: 10.3389/fncel.2021.644047

FIGURE 5.

FIGURE 5

The role of 5-HT and combination of ATP and 5-HT release events in firing of the WT and NaV1.1 mutant branching Aδ-fibers. (A) Firing of the WT (Kahlig et al., 2008) fibers (black line) and the L263V mutant (red line) activated by two 5-HT release events. (B) WT (Kahlig et al., 2008) fibers (black line) and the L263V mutant (red line) activated by ATP + 5-HT release events. (C) The L1670W mutant fiber (red line) and WT (Dhifallah et al., 2018) fiber (black line) activated by ATP + 5-HT release events. (D) The L1649Q mutant fiber (red line) and WT (Cestele et al., 2008) fiber (black line) activated by ATP + 5-HT release events. (E) The Q1478K mutant fiber (red line) and WT (Cestele et al., 2013) fiber (black line) activated by ATP + 5-HT release events. (F) The R1648H mutant (red line) and WT (Kahlig et al., 2006) fiber (black line) associated with childhood epilepsy gain-of-function of NaV1.1. (G) The M145T NaV1.1 mutant (red line) and WT (Mantegazza et al., 2005) fiber (black line) associated with a loss-of-function mutation of NaV1.1. ATP signaling is limited by partial hydrolysis and 5-HT signals are reduced by specific uptake.