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. 2021 May 31;15:644047. doi: 10.3389/fncel.2021.644047

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Copyright © 2021 Suleimanova, Talanov, van den Maagdenberg and Giniatullin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Firing activity of whole trigeminal meningeal nerve induced by persistent ATP plus 5-HT. (Aa) Firing activity of Na_V1.1 WT nerve induced by combined ATP (100 μM) and 5-HT (2 μM) action. (Ab) Firing activity induced by combined ATP (100 μM) and 5-HT (2 μM) action on nerve with fibers expressing L263V Na_V1.1 mutant channels. Notice details of fitting in insets. (Ba) The distribution of the inter-spike intervals (ISI) during action of ATP, 5-HT (Bb) and combined ATP + 5-HT action (Bc). ATP signaling is limited by partial hydrolysis and 5-HT signals are reduced by specific uptake.