Figure 2.

Recall rates for selected target disorders in neonatal screening in Germany from 2006 to 2018 Screening for congenital hypothyroidism, PKU/HPA (phenylketonuria/mild hyperphenylalaninemia) and MCAD deficiency (MCAD, medium-chain aAcyl-CoA dehydrogenase) shows a low recall rate (rate of positive screening results) even without second-tier procedures. In screening for CAH, the introduction of second-tier methods (additional analyses of the same blood sample in a second stage of examination) led to a distinct reduction in recall rate.