Table 2.
Baseline CMR Characteristics of Female Patients With Chemotherapy‐Naïve Cancer Compared With Healthy Volunteers
| Characteristic | Healthy Volunteers (n=55) | Patients With Cancer (n=300) | P Value |
|---|---|---|---|
| Age, y | 41.9±13.8 | 52.5±12.7 | <0.001 |
| BMI, kg/m2 | 24.1 (21.0‒27.7) | 26.5 (22.9‒30.8) | <0.001 |
| Heart rate, bpm | 64.7±10.3 | 71.5±11.7 | <0.001 |
| Systolic BP, mm Hg | 110.9±12.5 | 116.7±15.7 | 0.004 |
| Diastolic BP, mm Hg | 65.8±9.2 | 69.1±11.3 | 0.023 |
| CMR characteristics | |||
| Chamber volumes and mass (indexed to BSA) | |||
| LV EDV, mL/m2 | 77.9±12.0 | 68.1±11.8 | <0.001 |
| LV ESV, mL/m2 | 27.6±6.4 | 23.9±6.4 | <0.001 |
| LV EF, % | 64.8±5.0 | 65.1±5.5 | 0.65 |
| LV mass, g/m2 | 41.3±6.6 | 44.2±8.4 | 0.006 |
| LV stroke volume, mL/m2 | 50.3±7.8 | 44.1±7.3 | <0.001 |
| LV cardiac output, mL/m2 per min | 3.3±0.6 | 3.1±0.6 | 0.18 |
| RV EDV, mL/m2 | 83.1±12.7 | 69.3±12.6 | <0.001 |
| RV ESV, mL/m2 | 34.3±7.8 | 27.3±7.2 | <0.001 |
| RV EF, % | 59.0±5.0 | 60.9±6.1 | 0.013 |
| RV stroke volume, mL/m2 | 48.8±7.0 | 42.0±7.8 | <0.001 |
| RV cardiac output, mL/m2 per min | 3.2±0.6 | 3.0±0.6 | 0.022 |
| LA volume, mL/m2 | 34.7±6.0 | 30.2±8.1 | <0.001 |
| 3D‐MDA * | |||
| Circumferential strain amplitude, % | −11.1±1.8 | −11.8±1.8 | 0.008 |
| Longitudinal strain amplitude, % | −11.6±1.7 | −11.9±1.9 | 0.28 |
| Radial strain amplitude, % | 64.3±19.1 | 71.7±26.3 | 0.015 |
| Minimum principal strain amplitude, % | −27.0±2.3 | −28.7±2.6 | <0.001 |
| Maximum principal strain amplitude (%) | 88.8 (79.3‒95.8) | 102.4 (84.9‒125.0) | <0.001 |
| Systolic circumferential strain rate (1/s) | −0.88±0.15 | −0.93±0.15 | 0.037 |
| Systolic longitudinal strain rate (1/s) | −1.05±0.16 | −1.13±0.21 | 0.002 |
| Systolic radial strain rate (1/s) | 4.38 (3.90‒5.21) | 5.19 (4.06‒6.52) | 0.003 |
| Systolic minimum principal strain rate (1/s) | −1.75±0.35 | −1.87±0.34 | 0.018 |
| Systolic maximum principal strain rate (1/s) | 5.50 (4.67‒6.25) | 6.41 (5.13‒8.09) | <0.001 |
| Native T1 | |||
| Septum, ms † | 1143.5 (1121.3‒1161.0) | 1166.5 (1142.0‒1190.3) | <0.001 |
| Lateral wall, ms ‡ | 1130.0 (1096.3‒1165.8) | 1149.0 (1120.0‒1183.0) | 0.020 |
Values are mean±SD, median (IQR), or n (%). 3D‐MDA indicates three‐dimensional myocardial deformation analysis; BMI, body mass index; BP, blood pressure; BSA, body surface area; CMR, cardiovascular magnetic resonance; EDV, end‐diastolic volume; EF, ejection fraction; ESV, end‐systolic volume; LA, left atrium; LV, left ventricle; and RV, right ventricle.
*
Global values; available for 285 patients with cancer and 55 healthy volunteers.
†
Available for 238 patients with cancer and 38 healthy volunteers imaged at 3.0‐T.
‡
Available for 225 patients with cancer and 36 healthy volunteers imaged at 3.0‐T.