Table 4.
Independent Predictor Analysis
|
Primary End Point (Cardiac Death, Non–TV‐MI, Non‐TVR) |
Univariable Analysis n=617 HR (95% CI) |
P Value |
Multivariable Analysis n=571 HR (95% CI) |
P Value |
|---|---|---|---|---|
| Female sex | 1.23 (0.78–1.94) | 0.374 | ||
| Age, y (per 1‐y increase) | 1.03 (1.02–1.05) | <0.001 | 1.02 (1.00–1.04) | 0.061 |
| BMI, kg/m2 (per 1‐kg/m2 increase) | 1.02 (0.97–1.07) | 0.515 | ||
| Diabetes mellitus | 2.15 (1.34–3.43) | 0.001 | 1.63 (0.95–2.83) | 0.079 |
| Hypertension | 1.66 (1.11–2.50) | 0.015 | 1.14 (0.71–1.84) | 0.588 |
| Hypercholesterolemia | 1.26 (0.83–1.92) | 0.277 | ||
| Family history of CAD | 0.83 (0.53–1.29) | 0.402 | ||
| Killip III or IV | 7.71 (2.83–20.99) | <0.001 | 3.03 (0.89–10.33) | 0.077 |
| Left ventricular function, % (per 5% decrease) | 1.29 (1.17–1.43) | <0.001 | 1.25 (1.13–1.39) | <0.001 |
| MI SYNTAX score (per 5 points increase) | 1.39 (1.25–1.54) | <0.001 | 1.19 (1.05–1.34) | 0.007 |
| QFR ≤0.80 | 7.33 (4.54–11.83) | <0.001 | 7.75 (3.89–15.42) | <0.001 |
| DS ≥50% by 3D QCA | 2.63 (1.59–4.35) | <0.001 | 0.60 (0.28–1.28) | 0.187 |
Results from univariable and multivariable Cox proportional hazard analyses. Depicted are estimated hazard ratios (HRs) with 95% CI of the primary end point (cardiac death, spontaneous nontarget vessel myocardial infarction [non–TV‐MI], nontarget vessel revascularization [non‐TVR]) for patient baseline characteristics, quantitative flow ratio (QFR) ≤0.80, and diameter stenosis (DS) ≥50% by 3‐dimensional (3D) quantitative coronary angiography (QCA). Multivariable analysis was performed for variables with a significant association with the primary end point in univariable analysis. BMI indicates body mass index; CAD, coronary artery disease; and MI SYNTAX, Myocardial Infarction TAXus and Cardiac Surgery.