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. 2021 Apr 22;10(9):e019177. doi: 10.1161/JAHA.120.019177

Figure 1. Polyethylene glycol‐20k and MCC950 restored myocardial mitochondrial function after cardiac arrest and cardiopulmonary resuscitation.

Figure 1

Exemplary respirometric traces outlining the protocol applied in the high‐resolution respirometry experiment (A). Blue line indicates O2 concentration (μmol/L, left y‐axis), red line indicates O2 flux in pmol/(s×mL), right y‐axis. B, Routine respiration; (C), complex I‐linked respiration; (D), complex II‐linked respiration; (E), complex IV‐linked respiration; (F), respiratory control rates; (G), oxidative phosphorylation coupling efficiency. C indicates cardiac arrest control group; CI, complex I‐linked respiration; CII, complex II‐linked respiration; CIL , the non‐phosphorylating LEAK‐respiration; CIP , complex I‐linked phoshorylating capacity; CIIP , complex II‐linked phoshorylating capacity; CIVP , complex IV‐linked phoshorylating capacity; CIV, complex IV‐linked respiration; M, MCC950 group; MAP, mean artery pressure; OXPHOS, oxidative phosphorylation; P&M, polyethylene glycol‐20k‒MCC950 group, a highly selective NLRP3 inflammasome inhibitor; P, polyethylene glycol‐20k group; RCR, respiratory control rates; and S, sham control group without cardiac arrest. *P<0.05 vs S, # P<0.05 vs C, $ P<0.05 vs P, Ω P<0.05 vs M, respectively. All statistical analysis was performed by 1‐way ANOVA, followed by Tukey post‐hoc analysis (n=6 for each group). Each sample was measured in duplicate. Data are expressed as the mean±SD.