Skip to main content
. 2021 Apr 22;10(9):e019177. doi: 10.1161/JAHA.120.019177

Figure 5. Proposed mechanisms underlying the positive therapeutic effects of combined therapy with polyethylene glycol‐20k and MCC950 preserved myocardial function in a rat model of cardiac arrest and cardiopulmonary resuscitation.

Figure 5

Polyethylene glycol‐20k‒MCC950 combination exerts a protective effect by interrupting the mitochondrial vicious circle between mitochondrial permeabilization, release of mitochondrial danger‐associated molecular patterns, reactive oxygen species production, NLRP3 (the NOD‐like receptor family protein 3) inflammasome, cell swelling, and pyroptosis, and further mitochondrial damage. MCC950 is a highly selective NLRP3 inflammasomes inhibitor. I/R indicates ischemia‐reperfusion; IL‐1β, interleukin‐1β; IL‐18, interleukin‐18; MPTP, mitochondrial permeability transition pore; NLRP3, the NOD‐like receptor family protein 3; PEG‐20k, olyethylene glycol‐20k; PGC1‐α, peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha; ASC, apoptosis‐associated speck‐like protein; ROS, reactive oxygen species; S, the sham group; and SIRT1, sirtuin 1.