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. 2021 Apr 29;10(9):e018062. doi: 10.1161/JAHA.120.018062

Table 3.

Enriched Analysis of Co‐Expression of Differentially Expressed Genes

Expression Category Term Description Gene Count P Value
UP‐DEGs BP DNA replication initiation GO:0006270 5 2.57E‐05
BP Chromosome segregation GO:0007059 5 5.02E‐04
BP Cerebral cortex development GO:0021987 4 0.003142638
BP Mitotic nuclear division GO:0007067 4 0.004282494
BP Activation of protein kinase activity GO:0032147 3 0.006897187
CC Membrane GO:0016020 20 7.50E‐05
CC Nucleus GO:0005634 36 4.50E‐04
CC Mitotic spindle GO:0072686 4 0.00224541
CC Spindle microtubule GO:0005876 4 0.002462495
CC Cytoplasm GO:0005737 35 0.003611931
MF Adenosine triphosphate binding GO:0005524 18 0.009867326
MF Carnitine transmembrane transporter activity GO:0015226 2 0.024078878
MF DNA polymerase binding GO:0070182 2 0.024078878
MF Signaling pattern recognition receptor activity GO:0008329 2 0.024078878
MF Chromatin binding GO:0003682 7 0.030938733
DOWN‐DEGs BP Negative regulation of cell growth GO:0030308 6 3.70E‐04
BP Muscle contraction GO:0006936 5 0.002123639
BP Negative regulation of myotube differentiation GO:0010832 3 0.00290187
BP Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 3 0.003675669
BP Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 3 0.004094642
CC Z disc GO:0030018 8 2.22E‐06
CC Extracellular space GO:0005615 20 3.56E‐05
CC Proteinaceous extracellular matrix GO:0005578 8 4.16E‐04
CC Extracellular matrix GO:0031012 7 0.003871833
CC Calcium channel complex GO:0034704 3 0.007012586
MF Cytoskeletal protein binding GO:0008092 4 0.001632222
MF Calcium ion binding GO:0005509 10 0.007884453
MF Structural constituent of muscle GO:0008307 3 0.017698497
MF Calcium‐induced calcium release activity GO:0048763 2 0.019290714
MF Heparin binding GO:0008201 4 0.042979033

BP indicates biological processes; CC, cellular component; DEGs, differentially expressed genes; and MF, molecular function.