Table 3.
Hazard Ratios (95% CIs) of Incident Dementia by Carotid Plaque and cIMT Status: the ARIC Study, 1990 to 2017
| Plaque Absent | Plaque Present | Normal cIMT | Abnormal cIMT (>0.9 mm) | |
|---|---|---|---|---|
| Incident dementia, n | 1420 | 804 | 1815 | 409 |
| Incidence rate (per 1000 PY) | 7.88 | 10.08 | 7.96 | 12.81 |
| N at risk | 8337 | 4122 | 10 681 | 1778 |
| HR (95% CI) | ||||
| Model 1 | 1 (ref) | 1.10 (1.00–1.20) | 1 (ref) | 1.32 (1.18–1.48) |
| Model 2 | 1 (ref) | 1.07 (0.98–1.17) | 1 (ref) | 1.26 (1.12–1.40) |
| Model 3 | 1 (ref) | 1.06 (0.97–1.15) | 1 (ref) | 1.22 (1.09–1.36) |
| Model 4 | 1 (ref) | 1.02 (0.93–1.12) | 1 (ref) | 1.15 (1.03–1.29) |
Model 1: adjusted for age, sex, race/center, education, apolipoprotein E ɛ4. Model 2: adjusted for model 1 plus body mass index, systolic blood pressure, smoking status, pack‐years of smoking. Model 3: adjusted for model 2 plus antihypertensive medications, diabetes status. Model 4: adjusted for model 3 plus time‐varying stroke. ARIC indicates Atherosclerosis Risk in Communities; cIMT, carotid intima‐media thickness; HR, hazard ratio.