Table 1.
Important characteristics of patients with PAs in the low and high Ki-67 cohorts.
| Characteristics | Low Ki-67 | High Ki-67 | p |
|---|---|---|---|
| Age (year) | 53.48 ± 11.99 | 46.93 ± 13.69 | <0.001* |
| Gender | 0.687 | ||
| Female | 133 (52.2%) | 89 (49.7%) | |
| Male | 122 (47.8%) | 90 (50.3%) | |
| Clinical subtype | 0.003* | ||
| ACTH secreting | 7 (2.8%) | 4 (2.2%) | |
| GH secreting | 55 (22.2%) | 39 (21.8%) | |
| Nonfunctioning | 170 (68.5%) | 104 (58.1%) | |
| PRL secreting | 16 (6.5%) | 32 (17.9%) | |
| Primary-recurrence subtype | 0.170 | ||
| Primary | 218 (87.9%) | 143 (82.7%) | |
| Recurrence | 30 (12.1%) | 30 (17.3%) | |
| Maximum dimension (mm) | 26.23 ± 11.12 | 29.57 ± 12.57 | 0.010* |
| Knosp grade | 0.706 | ||
| Noninvasive | 123 (57.5%) | 74 (54.8%) | |
| Invasive | 91 (42.5%) | 61 (45.2%) | |
| Hardy grade for suprasellar extension | 0.009* | ||
| 0 | 61 (28.5%) | 23 (17.2%) | |
| A | 37 (17.3%) | 30 (22.4%) | |
| B | 62 (29%) | 36 (26.9%) | |
| C | 47 (22%) | 28 (20.9%) | |
| D | 5 (2.3%) | 8 (6%) | |
| E | 2 (0.9%) | 9 (6.7%) | |
| Hardy grade for sellar invasion | 0.696 | ||
| Noninvasive | 154 (72%) | 93 (69.4%) | |
| Invasive | 60 (28%) | 41 (30.6%) | |
| Multiple lesions | 0.033* | ||
| No | 213 (99.5%) | 129 (96.3%) | |
| Yes | 1 (0.5%) | 5 (3.7%) | |
| History of pituitary surgery | 0.046* | ||
| No | 223 (87.5%) | 143 (79.9%) | |
| Yes | 32 (12.5%) | 36 (20.1%) | |
| Prolacin (mIU/L) | 551.82 ± 796.05 | 909.36 ± 1190.74 | 0.001* |
| LH (IU/L) | 6.63 ± 8.31 | 4.09 ± 5.19 | 0.001* |
| FSH (IU/L) | 17.41 ± 20.23 | 10.20 ± 11.95 | <0.001* |
| T3 (nmol/L) | 1.25 ± 0.34 | 1.33 ± 0.40 | 0.058 |
| FT3 (pmol/L) | 4.24 ± 0.74 | 4.49 ± 1.06 | 0.046* |
| RBC count (1012/L) | 4.32 ± 0.50 | 4.42 ± 0.49 | 0.038* |
| MCV (fL) | 90.38 ± 4.36 | 88.55 ± 6.76 | 0.009* |
| MCH (pg) | 30.34 ± 1.72 | 29.57 ± 2.57 | 0.004* |
| Lymphocyte percentage (%) | 34.85 ± 9.01 | 36.61 ± 8.80 | 0.046* |
| Platelet count (109/L) | 197.93 ± 58.29 | 210.79 ± 56.78 | 0.017* |
| Thrombocytocrit (%) | 0.21 ± 0.06 | 0.22 ± 0.06 | 0.022* |
| FDP (μg/ml) | 2.31 ± 2.08 | 2.02 ± 1.82 | 0.040* |
| Potassium (mmol/L) | 4.06 ± 0.37 | 4.13 ± 0.35 | 0.045* |
| PCT (μg/L) | 0.05 ± 0.04 | 0.04 ± 0.02 | 0.011* |
| CRP (mg/L) | 3.04 ± 9.14 | 1.76 ± 4.29 | 0.049* |
| Creatinine (μmol/L) | 62.63 ± 18.48 | 59.46 ± 16.35 | 0.024* |
| Urea (mmol/L) | 5.34 ± 1.48 | 4.95 ± 1.34 | 0.004* |
ACTH secreting, adrenocorticotropic hormone secreting; GH secreting, growth hormone secreting; PRL secreting, prolactin secreting; LH, luteinizing hormone; FSH, follicle-stimulating hormone; T3, triiodothyronine; FT3, free triiodothyronine; RBC, red blood cell; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; FDP, fibrin/fibrinogen degradation products; PCT, procalcitonin; CRP, C-reactive protein.
*Statistical significance.