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. 2021 May 31;11:638311. doi: 10.3389/fonc.2021.638311

Figure 3.

Figure 3

sENO1+ CSCs are highly pro-metastatic. (A) Representative BLI of NOD/SCID mice receiving an intra-splenic injection of sENO1+ CSCs (represented by CD90+ NCI-N87 cells), sENO1- CSCs (CD90- NCI-N87 cells), and non-CSCs (represented by CD90- cells). at the indicated time following cell inoculation. (B) Tumor bulk quantified as BLI normalized photon counts as a function of time. Error bars represent mean ± SEM from one experiment (n = 8 mice per group). Unpaired t-test was performed throughout where **p < 0.01 versus non-CSCs. (C) Representative BLI of NOD/SCID mice receiving intra-splenic injection of sENO1+ CSCs (represented by CD90+ MKN-45 cells), sENO1- CSCs (CD90- MKN-45 cells) and non-CSCs (represented by CD90- cells). at the indicated time following cell inoculation. (D) Tumor bulk quantified as BLI normalized photon counts as a function of time. Error bars represent mean ± SEM from one experiment (n = 8 mice per group). Unpaired t-test was performed throughout where *p < 0.05 versus non-CSCs.