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. 2021 Jun 7;22(2):591. doi: 10.3892/ol.2021.12852

Figure 2.

Figure 2.

Downregulation of miR-4491 decreased the proliferation and induced the apoptosis of NSCLC cell lines. (A) miR-4491 expression was significantly increased in A549 and NCI-H1650 cells compared with that of BEAS-2B cells. A549 and NCI-H1650 cell transfection miR-4491 inhibitor decreased (B) miR-4491 expression and (C and D) cell proliferation and (E and F) increased cell apoptosis. A549 and NCI-H1650 cell transfection with miR-4491 mimic increased (G) miR-4491 expression and (H and I) cell proliferation. *P<0.05, **P<0.01 and ***P<0.001 vs. miR-NC mimic, miR-NC inhibitor or BEAS-2B cells. miR, microRNA; NSCLC, non-small cell lung cancer; NC, negative control.