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. 2021 Jun 7;22(2):591. doi: 10.3892/ol.2021.12852

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Downregulation of miR-4491 inhibited p65 protein expression by targeting TRIM7 in non-small cell lung cancer cell lines. (A) si-TRIM7 significantly decreased TRIM7 protein expression in A549 and NCI-H1650 cells. (B) Effect of si-TRIM7 was rescued by the miR-4491 inhibitor and resulted in decreased p65 protein expression in A549 and NCI-H1650 cells. ***P<0.001 vs. si-control or miR-NC inhibitor + si-control. ^&&P<0.01 and ^&&&P<0.001 vs. miR-4491 inhibitor + si-control. miR, microRNA; TRIM7, tripartite motif containing 7; NC, negative control; si, small interfering.