Table 1.

Potential therapies targeting FLG expression.

Targets
Gene-based approach: “Read-through” drugs
Direct replacement of FLG
Indirect replacement therapy: Topical application of FLG metabolites: PCA, UCA L-histidine
Inhibiton of cytokine-mediated FLG downregulation: IL-4/IL-13 inhibitors IL-13 inhibitors JAK inhibitors IL-22 inhibitors IL-17 inhibitors IL-24 inhibitors
Enhancement FLG expression: AHR agonists JTC-801 Peroxisome proliferator-activated receptors (PPARs) agonists Liver X receptor (LXR) agonists Sirtuin 1 (SIRT1) Apolipoprotein B mRNA editing enzyme complex (APOBEC3) Petrolatum, urea, glycerol Herbal medicines: apigenin, quercetin, luteolin, ursolic acid, rosmarinic acid