Table 1.
Patient characteristics by molecular classification.
| Characteristic | Molecular Classification | ||||
|---|---|---|---|---|---|
| MMRd (n = 6) |
POLE Mutated (n = 4) |
p53 Abnormal (n = 4) |
p53 Wild Type (n = 44) |
Total (n = 58) |
|
| Age at Diagnosis (years) | |||||
| Median (range) | 71.7 (51.9–86.8) | 55.5 (52.1–68.3) | 67.0 (48.1–89.0) | 53.1 (24.3–91.1) | 56.4 (24.3–91.1) |
| Diagnosis | |||||
| Endometrioid cancer | 4 (66.7) | 0 (0) | 1 (25.0) | 17 (38.6) | 22 (37.9) |
| Endometrial intraepithelial neoplasia | 2 (33.3) | 4 (100.0) | 3 (75.0) | 27 (61.4) | 36 (62.1) |
| Race, n (%) | |||||
| White | 4 (66.7) | 1 (25.0) | 2 (50.0) | 25 (56.8) | 32 (55.2) |
| Black | 1 (16.7) | 3 (75.0) | 2 (50.0) | 17 (38.6) | 23 (39.7) |
| Asian | 1 (16.7) | 0 (0) | 0 (0) | 0 (0) | 1 (1.7) |
| Other | 0 (0) | 0 (0) | 0 (0) | 2 (4.6) | 2 (3.5) |
| Ethnicity, n (%) | |||||
| Hispanic or Latino | 0 (0) | 0 (0) | 0 (0) | 4 (9.1) | 4 (6.9) |
| Not Hispanic or Latino | 6 (100.0) | 4 (100.0) | 4 (100.0) | 40 (90.9) | 54 (93.1) |
| Parity | |||||
| Median | 1.5 | 0.5 | 2.5 | 0.0 | 1.0 |
| BMI, kilograms/meter2 | |||||
| Median (range) | 43.0 (21.6–50.3) | 46.7 (35.5–53.3) | 37.5 (22.1–54.1) | 47.2 (19.9–74.4) | 46.4 (19.9–74.4) |
| ECOG Performance Score, n (%) | |||||
| 0–1 | 6 (100.0) | 2 (50.0) | 4 (100.0) | 27 (61.4) | 39 (67.2) |
| 2 | 0 (0) | 0 (0) | 0 (0) | 4 (9.1) | 4 (6.9) |
| 3 | 0 (0) | 0 (0) | 0 (0) | 2 (4.6) | 2 (3.5) |
| Unknown | 0 (0) | 2 (50.0) | 0 (0) | 11 (25.0) | 13 (22.4) |
| History of Other Cancer, n (%) | |||||
| No | 5 (83.3) | 3 (75.0) | 3 (75.0) | 38 (86.4) | 49 (84.5) |
| Yes | 1 (16.7) | 1 (25.0) | 1 (25.0) | 6 (13.6) | 9 (15.5) |
| Initial specimen obtained through, n (%) | |||||
| EMB | 1 (16.7) | 3 (75.0) | 2 (50.0) | 23 (52.3) | 29 (50.0) |
| D&C | 5 (83.3) | 1 (25.0) | 2 (50.0) | 21 (47.7) | 29 (50.0) |
| Hormonal therapy prior to LNG-IUS insertion, n (%) | |||||
| No | 6 (100.0) | 3 (75.0) | 4 (100.0) | 32 (72.7) | 45 (77.6) |
| Yes | 0 (0) | 1 (25.0) | 0 (0) | 12 (27.3) | 13 (22.4) |
| Imaging prior to LNG-IUSinsertion, n (%) | |||||
| No | 0 (0) | 0 (0) | 0 (0) | 15 (34.1) | 15 (25.9) |
| Yes | 6 (100.0) | 4 (100.0) | 4 (100.0) | 29 (65.9) | 43 (74.1) |
| Medical co-morbidities precluding surgery |
4 (66.7) | 4 (100.0) | 3 (75.0) | 22 (50.0) | 33 (56.9) |
| Placed at time of D&C | 0 (0) | 0 (0) | 0 (0) | 3 (6.8) | 3 (5.2) |
| Patient preference | 1 (16.7) | 0 (0) | 1 (25.0) | 6 (13.6) | 8 (13.8) |
Abbreviations: MMRd: mismatch repair-deficient; BMI: body mass index; ECOG: Eastern Cooperative Oncology Group; EMB: endometrial biopsy; D&C: dilation and curettage; LNG-IUS: levonorgestrel intrauterine system (LNG-IUS).