Table 3.
Nucleotide and amino acid substitutions in tumors with strong and diffuse expression of p53 by immunohistochemistry.
| Case | Initial Biopsy Histology | Nucleotide Mutation | Amino Acid Mutation | Mutation Type |
|---|---|---|---|---|
| 45 | EIN | c.877G > A | p.Gly293Arg | Amino acid substitution |
| 46 | EIN | c.517G > A p.210T > C c.693C > T |
p.Val173Met p.Ala70= p.Thr231= |
Amino acid substitution Silent mutation Silent mutation |
| 47 | EIN | c.651G > A | p.Val217= | Silent mutation |
| 48 | Grade 1 EC | c.548C > T c.817C > T |
p.Ser183Leu p.Arg273Cys |
Amino acid substitution Amino acid substitution |
Abbreviations: EC: endometrioid endometrial adenocarcinoma; EIN: endometrial intraepithelial neoplasia: Ser: serine; Leu: leucine; Arg: arginine; Cys: cysteine; Val: valine; Met: methionine; Ala: alanine; Thr: threonine, Gly: glycine.