Table 5.
Molecular characterization of patients with endometrioid endometrial intraepithelial neoplasia (n = 37) and outcome.
| Title | MMRd (n = 2) |
POLE- Mutated (n = 4) |
p53- Abnormal (n = 3) |
p53 Wild Type (n = 27) |
Total (n = 36) |
|---|---|---|---|---|---|
|
Progression or required definitive treatmentn (%) |
|||||
| No | 1 (50.0) | 3 (75.0) | 2 (66.7) | 25 (92.6) | 31 (86.1) |
| Yes | 1 (50.0) | 1 (25.0) | 1 (33.3) | 2 (7.4) | 5 (13.9) |
|
Type of definitive therapy, n (%) |
n = 1 |
n = 1 |
n = 1 |
n = 2 |
n = 5 |
| Surgery | 1 (100.0) | 0 (0) | 1 (100.0) | 2 (100.0) | 4 (80.0) |
| Radiation | 0 (0.0) | 1 (25.0) | 0 (0.0) | 0 (0.0) | 1 (20.0) |
|
Final diagnosis on hysterectomy specimen, n (%) |
n = 1 |
n = 0 |
n = 1 |
n = 2 |
n = 4 |
| No residual disease | 0 (0.0) | - | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| EIN | 0 (0.0) | - | 1 (100.0) | 0 (0.0) | 1 (25.0) |
| Cancer | 1 (100.0) | - | 0 (0.0) | 2 (100.0) | 3 (75.0) |
Abbreviations: MMRd: mismatch repair-deficient; EIN: endometrial intraepithelial neoplasia.