Table 6.

Examples of animal studies assessing the use of iron oxide-based nanoparticles in imaging.

Core-Shell Iron Oxide Agent	Imaging Modality	In Vivo Model	Reference
SPIONs coated with silica, APTES and (3-glycidoxypropyl) methyldiethoxysilane	MRI: medium T2 along with a minor effect on T1	Zebrafish (Danio rerio) model	[271]
Fe3O4 nanoparticles stabilized by PVP, trisodium citrate, and maleic anhydride	MRI-T2	White rabbit	[272]
IONPs coated with PEG		Tumour xenograft model on female NOD-SCID IL2 mice with human breast cell line (MDA-MB-231)	[235]
Luteinizing hormone-releasing hormone-conjugated PEG-coated magnetite nanoparticles		BALB/c nude mice (Triple negative breast cancer model)	[273]
Magnetic fibrin nanoparticles conjugated with folic acid		Albino Wistar rats with antigen-induced arthritis	[274]
HSA-coated iron oxide nanoparticles		BALB/c mice (breast cancer model with MDA-MB-231 cells)	[142]
PLA-PEG-D-glucosamine Fe3O4 nanoparticles	MRI-T2*	Tumour-bearing BABL/c mice inoculated with 4 T1 cells	[182]
PEG/PEI-SPIONs conjugated with transferrin		Kunming mice brain	[275]
USPIOs coated with carboxymethyldextran and coupled or not with a low-molecular-weight aminated fucoidan		Elastase-induced Wistar rat model	[141]
SPIONs coated with dextran and functionalized with anti-insulin-like-growth-factor binding protein 7 (anti-IGFBP7)	MRI-T2 and T2*	Nude CD-1 mouse model of glioblastoma multiforme	[276]